The Relationship between Plasma Taurine Levels and Diabetic Complications in Patients with Type 2 Diabetes Mellitus

The Relationship between Plasma Taurine Levels and Diabetic Complications in Patients with Type 2 Diabetes Mellitus

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Background: Taurine has an active role in providing glucose homeostasis and diabetes causes a decline in taurine levels.This paper investigates the relationship between taurine and diabetic complications, patients’ demographic features, and biochemical parameters.Methods: Fifty-nine patients with type 2 diabetes mellitus (T2DM), and 28 healthy control subjects between the ages of 32 and 82 were included in the study.

The mean age Belling Cookcentre 110DFT Professional Stainless Steel 110cm Dual Fuel Range Coo of subjects was 55.6 ± 10.3 and mean diabetes duration was 10.

2 ± 6.0 years.The most commonly accompanying comorbidity was hypertension (HT) (64.

5%, n = 38), and the most frequent diabetic complication was neuropathy (50.8%, n = 30).Plasma taurine concentrations were measured by an enzyme-linked immunoassay (ELISA) kit.

Results: Plasma taurine concentrations were significantly lower in diabetic patients (0.6 ± 0.1 mmol/L) than controls (0.

8 ± 0.2 mmol/L) and in hypertensive (0.6 ± 0.

1 mmol/L) patients (p = 0.000, p = 0.027 respectively).

Conclusion: Plasma taurine levels were decreased in patients with T2DM and this was not related to FBG, HbA1c, and microalbuminuria.With regard to complications, we NEFF C27CS22H0B BUILT-IN COMPACT OVEN STAINLESS STEEL TOUCH PYROLYTIC WIFI only found a correlation with neuropathy.We suggest that taurine levels may be more important in the development of diabetes; however, it may also have importance for the progression of the disease and the subsequent complications.

We further assert that taurine measurement at different times may highlight whether there is a causal relationship in the development of complications.